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1A) However, when assessing individual protein differences where a specific protein signal had to be present in at least 75% of the participants, we showed that 28 proteins were significantly increased, and 5 proteins significantly reduced in children affected with konzo versus unrelated/unaffected individuals (q 0.5) (Fig

10,14 The light, modifier subunit provides a regulatory function, while GCLC is responsible for the catalytic activity, which conjugates sulfur-containing cysteine with glutamate, forming -glutamylcysteine

Despite the promising findings reported in preclinical studies, it is important to emphasize that the majority of the available evidence originates from animal models and cell culture experiments

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